We maintain a list of research studies available for GP practices in Sheffield.
The list is largely, but not exclusively, drawn from the NIHR CRN Y&H portfolio of studies. The list is continually updated so please keep checking and contact the individual study team or the CRN Study Support Team if you have any queries.
The governance status of each study is colour coded in the ‘status’ column: red = assurance not yet issued. amber = assurance review in progress, green = assurance issued, grey = assurance not required.
| Name | Summary | Status | Last updated | PDF files/downloads |
| CANAssess | An RCT of a cancer patients’ needs assessment in primary care | Recruiting practices | 01.12.20 | CANAssess Poster PDF Invitation email Practices info Participant Info CANAssess EOI_v2.0 CANAssess RISP Model 2 Newsletter Jan 21 Newsletter Feb 21 Newsletter Mar 21 Newsletter Apr 21
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| CANAssess Research Portal | All the latest updates regarding CANAssess | Open | 17.12.20 | Website link |
| FRONTIER | Clinical and cost-effectiveness evaluation of first contact physios | Open | 19.10.20 | Summary PDF Infographic PDF |
| Principle Trial | The Principle Trial is evaluating potential treatments for COVID-19 in people aged over 50. | Open | 05.11.20 | Web link |
| ATTACK | The ATTACK trial will assess the effectiveness of low dose aspirin to prevent cardiovascular disease (CVD) in adult patients with chronic kidney disease(CKD). | Open | 05.11.20 | Web link |
| Virus Watch | Understanding community incidence, symptom profiles, and transmission of COVID-19 in relation to population movement and behaviour. | Open
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20.01.21 | Website link |
| Improving Healthcare through Clinical Research | A useful online course for clinical colleagues or volunteers with an interest in research. The course covers the history, theory and practice of clinical research. | Open to enrolment | 22.01.21 | Website link |
| Active Brains Study | The primary aim of this study is to assess the effectiveness and cost-effectiveness of a digital intervention (Active Brains) to help support older adults (60-85 years) with and without cognitive impairment in making healthy changes (physical activity, brain training, diet) to maintain cognitive function and prevent cognitive decline. | Open | 17.02.21 | Active Brains Study Summary Sheet Primary Care EOI template Study Protocol PIS online version |
| REDUCE WS5 (Reviewing Long Term Antidepressant Use By Careful Monitoring In Everyday Practice Work Stream 5) | The NHS funded six-year REDUCE research programme aims to identify feasible, safe, effective, and cost-effective ways of helping patients taking long-term antidepressants taper off and stop treatment, when appropriate. This Work Stream 5 (WS5) of the REDUCE programme aims to determine the effectiveness of online (Internet) interventions which support practitioners and guide patients on coming off antidepressants, together with psychological practitioner telephone calls to support the patients. | Open | 25.08.21 | Practices Info |
| Hypometrics Study | The Diabetes Research Team at STH are looking for GP practices to identify and approach people with Type 2 Diabetes on >1 insulin injections/day for inclusion into the Sheffield arm of the HypoMetrics Study. HypoMetrics will evaluate the impact of symptomatic as well as asymptomatic episodes of low sensor glucose on a variety of clinical, patient related and health economic outcomes such as mood, quality of sleep and productivity. | In set up | 27.08.21 | |
| PANORAMIC | A trial of oral antiviral treatment for COVID-19 in non-hospitalised patients | Open | 14.01.22 | Web link |
| GPs’ perspectives of online symptom checkers | The study team are looking to interview GPs who are working (or previously worked) in surgeries that are making use of online symptom checkers. The aim of the study is to explore GPs’ perspectives of the impacts of online symptom checkers such as DoctorLink in General Practice, and how this may affect the doctor-patient relationship, particularly with older patients. | Open | 12.01.22 | GPs participant info sheet and consent form |
| Understanding the implementation of link workers in primary care: A realist evaluation to inform current and future policy. | An National Institute for Health Research study to | Open | 27.01.22 | Poster to inform health professionals and VCS |
| GP working environment, roles and well-being | Researchers at the University of Sheffield are conducting a survey study looking at factors which may influence symptoms of burnout. | Open | 31.01.22 | Participant Info Sheet |
| IDENTI-Pall | Patient views and experiences of the identification of their palliative care needs (IDENTI-Pall) | Open | 14.02.22 | GP Info Sheet Participant Info Sheet (Patients) |
| ALABAMA (ALlergy AntiBiotics And Microbial resistAnce) | ALABAMA is a randomised controlled trial to evaluate whether the Penicillin allergy assessment pathway (PAAP) intervention is clinically effective in improving patient health outcomes. GP practice involvement is mainly related to patient identification i.e. electronic searches and application of inclusion/exclusion criteria. Based on an estimated recruitment of 21 per practice payment will be in the region of £2000. | In set up | 07.03.22 | Invitation PDF |
| E.mbrace | Randomized, Double-Blind, Placebo-controlled, Multicenter Phase 3 Study to Assess the Efficacy, Safety And Immunogenicity of Vaccination With ExPEC9V in the Prevention of Invasive Extraintestinal Pathogenic Escherichia coli Disease in Adults Aged 60 Years And Older with a History of Urinary Tract Infection in the Past 2 Years. | Open | 02.08.22 | Amending an approval Study Assurance Letter |
| PARTICIPANTS REQUIRED: Your Views on Digital Health Promotion in Youth Mental Health” | We are looking for young adults (e.g. aged 16 – 30) who are currently receiving treatment / care for a mental health condition to help with a new study. The study is been conducted as a survey to get young people’s views on the possible uses of smartphones and health apps for helping to improve physical health. Participants will be asked to complete a 10-15 minute survey, sharing their opinions and ideas around potential uses of technology for this purpose. We hope to use this valuable input from participants in future, to help explore new ways of improving physical health in youth mental healthcare. |
Open | 02.08.22 | Survey link here Leaflet here |
| Commercial Study – RSV | This project is looking for healthy term and preterm infants during the first year of life entering their first RSV (respiratory syncytial virus) season. The project involves a single intramuscular dose of nirsevimab in the prevention of hospitalisations due to RSV infections in healthy infants. The study vaccine can be co-administered along with mandatory paediatric vaccines planned in the standard of care vaccination schedule. This project is delivered in collaboration between Sanofi & NIHR. Currently, we have 5 secondary care NHS sites within the Yorkshire & Humber region ready (or almost ready) to offer participation in this project to their patients. |
Open | 11.10.22 | Read more here |
| Supervised Pulmonary Hypertension Exercise Rehabilitation (SPHERe) Trial |
We want to find out if exercise rehabilitation can be done at home with online (remote) supervision from trained exercise specialists. We have developed a new exercise programme, with motivational support, to encourage people to exercise for eight weeks. We now want to find out if this programme is better than usual NHS care for people with pulmonary hypertension. | Open | 11.10.22 | Visit website here See poster here |
